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Rogier Van Der Weyden | The Descent from the Cross, c. 1435

The Descent from the Cross was commissioned by the Greater Guild of Crossbowmen of Leuven in today's Belgium and was originally installed in the Chapel of Our Lady Without the Walls. The tiny crossbows in the side spandrels of the picture reflect the original patronage. De Vos and Campbell both give an approximate date of 1435 for the painting.
De Vos argues that the earliest known copy of Van der Weyden's Deposition, the Edeleheere triptych in Leuwen, may have been completed by 1435, certainly before 1443. This implies that Van der Weyden's painting pre-dates it. The painting was exchanged around 1548 for a copy by Michael Coxcie and an organ.